Last edited by Samugor
Saturday, August 1, 2020 | History

2 edition of Ensnaring the pancreatic alpha-cell, and, Syntaxin 1A modulation of the alpha-cell Kv4.3 channel. found in the catalog.

Ensnaring the pancreatic alpha-cell, and, Syntaxin 1A modulation of the alpha-cell Kv4.3 channel.

Ishtiaq Ahmed

Ensnaring the pancreatic alpha-cell, and, Syntaxin 1A modulation of the alpha-cell Kv4.3 channel.

by Ishtiaq Ahmed

  • 241 Want to read
  • 19 Currently reading

Published .
Written in English


About the Edition

Immunohistochemical and electrophysiological characterization of alpha- and beta-cells confirmed the viability of the GFP-labelling technique for examining islet cells. Furthermore, we demonstrated a large variance in beta-cell sizes with potential functional consequences.Pancreatic islet alpha- and beta-cells secrete glucagon and insulin respectively to maintain glucose homeostasis. Study of alpha-cells is limited by difficulties in isolating and identifying them and therefore little is known concerning regulation of alpha-cell membrane excitability and exocytosis. This thesis (1) assesses a new technique for efficient detection of alpha-cells in a transgenic mouse model expressing GFP-labelled beta-cells and (2) subsequently studies the alpha-cell Kv4.3 channel and its potential regulation by syntaxin 1A (Syn1A), a SNARE protein involved in modulating cell excitability and exocytosis.Our results also indicate that Kv4.3, which significantly shapes action potentials, is less responsive to Syn1A induced inhibition than other Kv channels and that Syn1A - Kv interactions are diverse and dynamic in nature.

The Physical Object
Pagination130 leaves.
Number of Pages130
ID Numbers
Open LibraryOL19215949M
ISBN 109780494163900


Share this book
You might also like
Biophilosophie auf erkenntnistheoretischer Grundlage.

Biophilosophie auf erkenntnistheoretischer Grundlage.

Society and Caste.

Society and Caste.

Survival tactics

Survival tactics

Pediatric emergency assessment, recognition, and stabilization

Pediatric emergency assessment, recognition, and stabilization

Periodicals news from the National Reference Library of Science and Invention.

Periodicals news from the National Reference Library of Science and Invention.

Natural history, classification, reconstructed phylogeny, and geographic history of Pytho Latreille (Coleoptera, Heteromera, Pythidae)

Natural history, classification, reconstructed phylogeny, and geographic history of Pytho Latreille (Coleoptera, Heteromera, Pythidae)

Schaums outline of theory and problems of electromagnetics

Schaums outline of theory and problems of electromagnetics

Summary of cooperative research programs

Summary of cooperative research programs

The Cruise of H.M.S. New Zealand

The Cruise of H.M.S. New Zealand

Report on the area based response to long term unemployment 1991-1993.

Report on the area based response to long term unemployment 1991-1993.

English men and menners in the eighteenth century.

English men and menners in the eighteenth century.

Estimates of undiscovered oil & gas resources

Estimates of undiscovered oil & gas resources

Woodworking for beginners

Woodworking for beginners

Ensnaring the pancreatic alpha-cell, and, Syntaxin 1A modulation of the alpha-cell Kv4.3 channel by Ishtiaq Ahmed Download PDF EPUB FB2